Email:[email protected]
个人简介
蒋玉辉，中共党员，教授，博士生导师，入选国家级高层次青年人才、上海市青年科技启明星计划、上海市青年拔尖人才，任中华医学会消化病学分会第十一届委员会胰腺病学组委员；2006年6月获湖南师范大学生命科学学院学士学位，2011年7月获中科院上海生科院营养科学研究所博士学位，2011年9月至2015年6月在美国得州大学MD安德森癌症中心从事博士后研究；工作经历上，2015年7月至2019年7月任上海交通大学附属第一人民医院研究员，2019年12月至2024年10月任上海交通大学医学院附属仁济医院研究员，2024年11月起任 happy漫画
教授。
本课题组研究聚焦于细胞代谢网络调控与药理学，围绕代谢酶调控生理活动进而影响肿瘤生长、代谢酶与生长因子信号互作等关键科学问题展开，研究关键词包括代谢调控、代谢检测、代谢酶等。以通讯作者在Nature Cell Biology、Nature Structural & Molecular Biology、Nature Metabolism、Molecular Cell、Nature Communications、Cell Reports等权威期刊发表多篇论文，获国内发明专利授权2项，主持国家重点研发计划专项课题、国家自然科学基金联合基金项目（重点支持项目）及面上项目，获中国药学会科学技术奖一等奖、上海药学科技奖一等奖。
主要研究方向
细胞代谢网络调控与药理学
获奖情况
1. 2025年 中国药学会科学技术奖一等奖
2. 2023年 上海药学科技奖一等奖
4. 2016年 上海高校青年东方学者
5. 2016年 上海市青年科技启明星计划
6. 2015年 上海市青年拔尖人才
7. 2015年 USCACA-AFCR Scholar Awardees
代表性论著（*共同通讯作者）
1. Bei Zhou; Qin Zhao; Guofang Hou; Jing He; Nannan Sha; Ke Zheng; Hongyu Peng; Wang Wang; Yue Zhou; Tao Chen; Yuhui Jiang; IMPDH2 dephosphorylation under FGFR signaling es S-phase progression and tumor growth, Cell Reports, 2025, 44(1): 115116.
2. Nannan Sha; Bei Zhou; Guofang Hou; Zhifeng Xi; Wang Wang; Man Yan; Jing He; Yue Zhou; Qiang Xia; Yuhui Jiang*; Qin Zhao; The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation, Oncogene, 2025, 44(16):1078-1092.
3. Jing He; Aoxue Wang; Qin Zhao; Yejun Zou; Zhuo Zhang; Nannan Sha; Guofang Hou; Bei Zhou; Yi Yang; Tao Chen; Yuzheng Zhao; Yuhui Jiang*; RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth, Nature Structural & Molecular Biology, 2024, 31(9): 1413-1425.
4. Yuzheng Zhao; Yuhui Jiang*; HES4 controls redox balance and supports pyrimidine synthesis and tumor growth, Nature Structural & Molecular Biology, 2024, 31(9): 1315-1316.
5. Ke Zheng; Nannan Sha; Guofang Hou; Zhuyun Leng; Qin Zhao; Li Zhang; Lingnan He; Meidong Xu; Yuhui Jiang*; Tao Chen; IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia, Nature Communications, 2023, 14(1): 6117.
6. Shupei Wei; Qin Zhao; Ke Zheng; Peiying Liu; Nannan Sha; Yingzi Li; Chunmin Ma; Jingjie Li; Lingang Zhuo; Guanxin Liu; Wenhua Liang; Yuhui Jiang*; Tao Chen; Nanshan Zhong; GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and es lung cancer cell survival under glucose starvation, Cell Discovery, 2022, 8(1): 77.
7. Chunmin Ma; Ke Zheng; Kun Jiang; Qin Zhao; Nannan Sha; Wang Wang; Man Yan; Tao Chen; Yuzheng Zhao; Yuhui Jiang*; The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress, Nature Metabolism, 2021, 3(10): 1357-1371 .
8. Qin Zhao; Ke Zheng; Chunmin Ma; Jingjie Li; Lingang Zhuo; Wenhua Huang; Tao Chen; Yuhui Jiang*; PTPS facilitates compartmentalized LTBP1 S-nitrosylation and es tumor growth under hypoxia, Molecular Cell, 2020, 77(1): 95-107.
9.Tao Chen; Ting Wang; Wenhua Liang; Qin Zhao; Qiujing Yu; Chun-Min Ma; Lingang Zhuo; Dong Guo; Ke Zheng; Chengzhi Zhou; Shupei Wei; Wenhua Huang; Juhong Jiang; Jing Liu; Shiyue Li; Jianxing He; Yuhui Jiang*; Nanshan Zhong; PAK4 phosphorylates fumarase and blocks TGFβ-induced cell growth arrest in lung cancer cells, Cancer Research, 2019, 79(7): 1383-1397.
10. Jingjie Li; Bin Hu; Ting Wang; Wenhua Huang; Chunmin Ma; Qin Zhao; Lingang Zhuo; Tao Zhang; Yuhui Jiang; C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer, Molecular Cancer, 2018, 17(1): 174.
11. Ting Wang; Qiujing Yu; Jingjie Li; Bin Hu; Qin Zhao; Chunmin Ma; Wenhua Huang; Lingang Zhuo; Houqin Fang; Lujian Liao; Y. Eugene Chin; Yuhui Jiang*; O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency, Nature Cell Biology, 2017, 19(7): 833- 843.
12. Tao Chen; Jingjie Li; Meidong Xu; Qin Zhao; Yingyong Hou; Liqing Yao; Yunshi Zhong; Ping Chieh Chou; Wei Zhang; Pinghong Zhou; Yuhui Jiang*; PKCε phosphorylates MIIP and es colorectal cancer metastasis through inhibition of RelA deacetylation, Nature Communications, 2017, 8(1): 939.
13. Yuhui Jiang; Xu Qian; Jianfeng Shen; Yugang Wang; Xinjian Li; Rui Liu; Yan Xia; Qianming Chen; Guang Peng; Shiaw-Yih Lin; Zhimin Lu; Local generation of fumarate es DNA repair through inhibition of histone H3 demethylation, Nature Cell Biology, 2015, 17(9): 1158- 1168.
14. Yuhui Jiang; Xinjian Li; Weiwei Yang; David H. Hawke; Yanhua Zheng; Yan Xia; Kenneth Aldape; Chongyang Wei; Fang Guo; Yan Chen; Zhimin Lu; PKM2 regulates chromosome segregation and mitosis progression of tumor cells, Molecular Cell, 2014, 53(1): 75-87.
15. Yuhui Jiang; Yugang Wang; Ting Wang; David H. Hawke; Yanhua Zheng; Xinjian Li; Qin Zhou; Sadhan Majumder; Erfei Bi; David X. Liu; Suyun Huang; Zhimin Lu; PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells, Nature Communications, 2014, 5: 5566.
